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No certain dose adjustment advised when tofacitinib coadministered with strong CYP2C19 inhibitors; reduce tofacitinib dose if coadministered with both equally moderate CYP3A4 and powerful CYP2C19 inhibitors .It had been clinically found that modafinil influences pharmacodynamics of medication that are metabolized by CYP3A4 together with other enzym

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